CREB1 and ischemia: Moreover, the endogenous astrocytes appeared more branched around BDNF positive vessels (Becerra-Calixto and Cardona-Gómez, 2016; Becerra-Calixto et al., 2018), which have been involved in the recovery of LTP synaptic plasticity and CREB phosphorylation in the neuroprotection by CDK5 KD in ischemia (Gutiérrez-Vargas et al., 2016).