It should be noted that even though CGRP is highly expressed in rodent and human fibers projecting to the brainstem (Eftekhari and Edvinsson, 2011), which is active and plays a role in migraine pathophysiology, no study has evaluated the role of male vs. female brainstem in migraine (Maleki and Androulakis, 2019). The gene discussed is CALCA; the disease is migraine disorder.