TRPC4 and migraine disorder: While hypersensitivity to touch is present in many migraineurs and cutaneous mechanical allodynia is well characterized in the NTG animal model of migraine (Mathew et al., 2004; Pradhan et al., 2014; Lipton et al., 2017), additional animal models and symptoms associated with migraine should be explored to validate the inhibition of TRPC4 as a novel therapeutic approach.