Mutations in TRPA1, TRPV1, and TRPM8 have been linked to migraine (Chasman et al., 2011; Carreño et al., 2012; Ghosh et al., 2013; Dussor et al., 2014; Fan et al., 2014; Benemei and Dussor, 2019; Kowalska et al., 2020). This evidence concerns the gene TRPV1 and migraine disorder.