Furthermore, a missense substitution (Glu111Ala) and heterozygous frameshift mutations were recently shown to significantly decrease the Glo-1 protein expression and enzymatic activity in the red blood cells (RBCs) from Japanese patients with schizophrenia (Arai et al., 2010; Miyashita et al., 2014a,b; Torii et al., 2020). Here, GLO1 is linked to schizophrenia.