The involvement of GABRP in ERK regulation was further highlighted when the administration of U0126, a MAPK/MEK inhibitor, eliminated the invasive and pro-migratory abilities of SK-OV-3 cells, suggesting that GABRP modulates the MAPK/ERK pathway to enhance the metastatic potential of ovarian cancer 28. This evidence concerns the gene GABRP and ovarian carcinoma.