The target genes of the mTOR pathway, including p-p70S6K, p-4EBP1, MYC, Cyclin D1, HIF1α, and SREBP1, were also positively regulated by UBE2O in HCC cells (P<0.05, Figure 4B and 4D and Supplementary Figure 5). Here, EIF4EBP1 is linked to hepatocellular carcinoma.