MAPT and dementia: Further, they found that Aβ potentiates the effects of microglial activation on tau spreading.92 More importantly, co-occurrence of Aβ, tau and microglia abnormalities seems necessary for a full-bloom dementia phenotypes.92 These results, while correlative, are consistent with our finding that Aβ deposites occurred first, and microglial activation and tau pathology co-increase from 6-month to 12-month in the AppNL-G-F rat model.