RNF19A and cancer: Importantly, RNF19A WT, but not RNF19A R1, was able to reverse the increase in HR repair caused by RNF19A deficiency (Fig. 2i) and re-sensitize cells to PARPi (Fig. 2j), suggesting that the RNF19A/BARD1 interaction is essential for HR regulation and cancer cell response to PARPi.