The glioma induced cytokines TGF-β, prostaglandin \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$E_{2}$$\end{document}E2 and IL-10 suppress the activity of immune system and stimulate the production of malignant gliomas. The gene discussed is TGFB1; the disease is central nervous system cancer.