BEND6 and small cell lung carcinoma: Furthermore, two negative regulators of Notch signalling, BEN domain containing 6 (BEND6)27 and delta-like 1 homolog (DLK1)28 were downregulated in the CDX progression models (twofold and threefold, respectively, p < 0.001, Supplementary Data 1) consistent with elevated Notch pathway activity, so we asked whether Notch could regulate sGC subunit expression in SCLC.