PTEN and renal fibrosis: In addition, RPTC-specific PTEN overexpression increased proliferating cell nuclear antigen (PCNA) levels and E-cadherin re-expression and alleviated renal fibrosis, as indicated by reduced Masson and Sirius red-positive areas, as well as the levels of fibrotic proteins (Fig. 3C–E and SFig. 2I).