For example, although the low T-cell infiltration, low immune score, and low PD-L1 expression suggested an overall cold immune response rather than the high level of adaptive immune evasion in these SCLC tumors, the high prevalence of HLA LOH suggested that active adaptive immune suppression may have taken place at some point during early evolution of these SCLC tumors. The gene discussed is CD274; the disease is small cell lung carcinoma.