CRP and Brain atrophy: Participants with a higher inflammatory burden on average had greater overall brain atrophy, with higher DNAm CRP associating with lower total brain volume (β = −0.197, 95% CI −0.28 to −0.12, pFDR = 8.42 × 10−6), GM volume (β = −0.200, 95% CI −0.28 to −0.12, pFDR = 1.66 × 10−5), and WM volume (β = −0.150, 95% CI −0.23 to −0.07, pFDR = 0.001).