DNAm CRP is associated with total brain volume (β = −0.197, 95% confidence interval [CI] −0.28 to −0.12, pFDR = 8.42 × 10−6), gray matter volume (β = −0.200, 95% CI −0.28 to −0.12, pFDR = 1.66 × 10−5), and white matter volume (β = −0.150, 95% CI −0.23 to −0.07, pFDR = 0.001) and regional brain atrophy. The gene discussed is CRP; the disease is Brain atrophy.