Formed by proteolytic processing of amyloid precursor protein (APP), Aβ peptide self-associates to form soluble oligomers and fibrils before eventually depositing into the hallmark plaques associated with AD (Seubert et al., 1992; Shoji et al., 1992; Lambert et al., 1998; Gong et al., 2003; Lesné et al., 2006). Here, APP is linked to Alzheimer disease.