Evidence from Taiwanese aboriginal studies showed that the V-A-T haplotype within the UCP2-UCP3 gene cluster increased the aboriginal’s risk for obesity [39], the frequency distribution of the risky allele of UCP2 (A-3751G) between indigenous and Han peoples was significantly different [40], and a genetically recessive role of the LEP −2548 G/G homozygote in developing extreme obesity for aborigines was suggested [36]. The gene discussed is UCP3; the disease is obesity due to melanocortin 4 receptor deficiency.