For genes associated with our agnostic LASSO ever versus never smoker score (N = 21), BioPlanet 2019 (biological) pathways showed enrichment for haemostasis, platelet homeostasis, G alpha (s) signalling events, chromatin remodelling by nuclear receptors to facilitate initiation of transcription in carcinoma cells, and the rapid glucocorticoid receptor pathway. Here, NR3C1 is linked to carcinoma.