After treatment, the significant increased SOD activity was observed in CIS mice treated with TGN/SHp/TPP-MLT micelles (TGN/SHp/TPP-MLT micelles vs. TPP-MLT, 15.86 ± 0.42 U/mg prot vs. 15.86 ± 0.42 U/mg prot). This evidence concerns the gene SOD1 and in situ carcinoma.