JAK2 and glaucoma: In addition, TRPV4 activation could enhance the release of inflammatory cytokines (e.g., tumor necrosis factor-α [TNF-α]) through JAK2/STAT3/NF-kB signaling pathways in Müller cells and elevated expression of TNF receptor 1 in RGCs; this process is involved in RGC apoptosis during glaucoma.