The protein expressions of Cleaved caspase-3, Cleaved caspase-9 and Bax were significantly higher in PSVII@MCP-CaP treated group than in PSVII treated group, indicating PSVII@MCP-CaP displayed much stronger capability in inducing apoptosis of drug-resistant colon cancer tissue than that of PSVII. Here, CASP9 is linked to colonic neoplasm.