Western blot results of orthotopic drug-resistant colon cancer tissues are showing in Fig. 8B, C. As compared with model group, the protein expressions of P-gp and Bcl-2 in orthotopic resistant colon cancer tissues were significantly decreased after treatment with PSVII and PSVII@MCP-CaP, and the protein expressions of Cleaved caspase-3, Cleaved caspase-9 and Bax were significantly increased. Here, CASP3 is linked to colonic neoplasm.