STAT3 and breast carcinoma: Meanwhile, miR-365a-3p mimic reduced the SP ratio in MDA-MB-231 and MDA-MB-468 cells, while the STAT3 overexpression reversed the inhibition (Fig. 7D and E), implying that the overexpression of STAT3 rescues miR-365a-3p-inhibited proliferation and cancer stem cell activity of breast cancer.