The downregulated genes were clustered into 27 subcategories (p < 0.05; 10 subcategories with p < 0.01), including the tumor necrosis factor (TNF) signaling pathway (p = 3.92*E-05), small cell lung cancer (p = 0.0012), p53 signaling pathway (p = 0.003), nuclear factor-kappa B (NF-κB) signaling pathway (p = 0.005) and cell cycle (p = 0.017) (Fig. 6B, Supplementary Table S5A). This evidence concerns the gene TNF and small cell lung carcinoma.