MDM4 and central nervous system cancer: Copy-number events that showed significant associations with later-onset cases aggregated in LGG: deletions of PTEN (FDR = 0.026), CDKN2A (FDR = 1.78E-4), and CDKN2B (FDR = 1.16E-4) as well as amplifications of MDM4 (FDR = 0.011) and EGFR (FDR = 1.43E-8) were each significantly associated with later-onset gliomas (Figure 3B).