HES4 and glioma: HES4-methylated IDHwt (FDR = 9.58E-3) and NOV-methylated IDHwt (FDR = 0.010) gliomas were both significantly enriched in the later-onset cohort, along with HES4-methylated IDHmut-codel (FDR = 0.015) and TCF7-methylated IDHmut-codel (FDR = 0.016) gliomas (Figures 4C and S4C).