We found significant enrichment of GATA3-mutated luminal A BRCA in young adults (FDR = 3.11E-3, Figures 2B and S2B), as well as significant enrichment of TP53, IDH1, and ATRX-mutated IDHmut-non-codel gliomas in the same cohort (FDR ≤ 4.64E-10, Figures 2C and S2C). This evidence concerns the gene ATRX and central nervous system cancer.