IFNG and sarcoma: Young adult sarcomas present diminished lymphocyte infiltration, IFN-γ response, M1 macrophages, and Th1 response (Figures 6B and 6C): together, these features would predict reduced survival time and poor treatment response (Brown et al., 2017; Lugade et al., 2008; Maimela et al., 2019; Thorsson et al., 2018).