In the multivariate analysis correcting for covariates (Figure 3B), ERBB2 copy-number amplification was not significantly associated with age in BRCA (p = 0.35), whereas CDK4 amplification was associated with later-onset LGG (p = 0.010), validating recently published findings in a Japanese glioblastoma cohort (Fukai et al., 2020). This evidence concerns the gene CDK4 and glioblastoma.