ARRDC1 and central nervous system cancer: We also identified significant enrichments of both CCND2-amplified IDHmut-non-codel (FDR = 0.019) and KDM5A-amplified IDHmut-non-codel (FDR = 0.042) gliomas in young adults, along with suggestive enrichments of KRAS amplified IDHmut-non-codel (FDR = 0.108) and ARRDC1 amplified IDHmut-non-codel (FDR = 0.108) gliomas (Figures 3D and S3F).