Across different cancer types, SV-mediated alterations (Figure S2) involved receptor tyrosine kinase (RTK) pathway-related genes (KRAS, ERBB2), p53/Rb-related genes (CCND1, CCNE1, CDK4, CDKN2A, MDM2), TERT, MYC family genes (MYC, MYCN), and mTOR pathway-related genes (PTEN, STK11). This evidence concerns the gene MDM2 and cancer.