176 Regarding the efficacy of omega-3 VLC-PUFAs as a treatment for STGD3, a recent long-term clinical study testing diets supplemented with omega-3 VLC-PUFAs, such as EPA and DHA, in STGD3 patients found no changes in the disease progression.278 Dietary DHA supplementation was also tested in mice with a mutant ELOVL4 allele but these studies yielded conflicting results.279,280 This could be due to the differential effect of the mutant ELOVL4 and Elovl4 allele on VLC-PUFA synthesis in the mouse retina. This evidence concerns the gene ELOVL4 and Stargardt disease 3.