APOA1 and cardiovascular disorder: HDL particles that harbor ApoA1 are critical for reverse cholesterol transport, which removes lipids from cells and provides anti-inflammatory protection.284 ApoA1 mimetics vary in peptide length and promote reverse cholesterol transport and are anti-inflammatory.285 However, the effectiveness of ApoA1 mimetics as a cardiovascular disease treatment has been variable with some reports indicating no beneficial changes in patients.286–288 and others describing increased HDL function in patients.289