Nonhuman primates are ideal models due to the presence of a macula, drusen in aged animals,89 and shared common AMD susceptibility genes such as age-related maculopathy susceptibility 2 (ARMS2)/HtrA serine peptidase 1 (HTRA1),90 but these animals are very costly to maintain and have a slow disease progression. This evidence concerns the gene HTRA1 and age-related macular degeneration.