ApoA-1 is a major protein constituent of HDL, a lipoprotein associated with AMD risk.48–51 In the posterior eye, the major site of interaction between CFH and HDL occurs at heparan sulfation within BrM.22,240 We postulate that augmenting CFH concentrations or soluble heparan sulfate in the posterior eye may prevent toxic accumulations of lipoproteins such as HDL in BrM and protect against RPE damage and death. This evidence concerns the gene APOA1 and age-related macular degeneration.