There are 10 highly significant, direct and physical associators with a confidence score of ≥5.0 namely – RELA, HMOX2, EZH2, p-10Y-ERBB3-1, WDR1, ERRFI1, PRG2, FMR1, DEFA6-(?-100), cytf_human and the majority of the network associators of POTEE are epigenetically activated in many cancers. The gene discussed is HMOX2; the disease is cancer.