Thus, although B cell expression of CD20 and/or FcγRIIb was variable between individuals and also in B cell subpopulations, the findings described here suggest that the thresholds of B cell expression of CD20 and FcγRIIb and/or baseline composition of B cell subpopulations do not seem to influence the efficiency of anti-CD20 mAbs in inducing BCD, in vitro, in RA and SLE patient samples. Here, FCGR2B is linked to systemic lupus erythematosus.