In 42 patients with IBD and 10 healthy individuals, Singh et al. showed that serum levels of macrophage migration factor (MIF), CCL21, CCL23, CCL25, CXCL5, CXCL10, CXCL11, CXCL13, MCP-1 were increased in patients with IBD compared with healthy subjects [6]. This evidence concerns the gene CCL21 and inflammatory bowel disease.