We investigated the effects of PLIN and αSyn expression on LD formation in photoreceptor neurons; the role of canonical mechanisms regulating LD metabolism; the subcellular co-localization of αSyn with LDs in Drosophila photoreceptors neurons and in human neuroblastoma cells; the potential contribution of αSyn with several LD proteins to the inhibition of lipolysis and the subsequent LD formation; and the potential effects of αSyn–LD binding on the susceptibility of αSyn to misfolding in the context of PD. The gene discussed is PLIN1; the disease is neuroblastoma.