PGC and systemic lupus erythematosus: PGC-1αPV−/− brain slices experienced a significantly larger number of preictal events before the first SLE (Fig. 2B, WT, n = 6; means ± standard deviation, 14.7 ± 4.5 preictal events per slice, with a range 9–22; PGC-1αPV−/−, n = 10; 84.6 ± 52.0 preictal events/slice, range 22–193; Wilcoxon rank sum, P = 0.0005) relative to control brain slices, which cumulatively represented a much longer duration of pathological activity (Fig. 2C).