It is relevant, therefore, that reduced PGC-1α expression has been found in a number of neurological conditions (4), including Parkinson’s disease (20), Alzheimer’s disease (21, 22), Huntington’s disease (23), multiple sclerosis (24), and schizophrenia (25, 26), but interestingly, not epilepsy. The gene discussed is PPARGC1A; the disease is schizophrenia.