It is relevant, therefore, that reduced PGC-1α expression has been found in a number of neurological conditions (4), including Parkinson’s disease (20), Alzheimer’s disease (21, 22), Huntington’s disease (23), multiple sclerosis (24), and schizophrenia (25, 26), but interestingly, not epilepsy. This evidence concerns the gene PPARGC1A and epilepsy.