APC and neoplasm: To analyze how longer-term Lef1 deletion affects tumor development after a stochastic loss of the remaining WT Apc allele in ApcMin/+ mice, we compared tumor growth in ApcMin/+(ApcMin), Villin-Cre;ApcMin/+;Lef1fl/+(VApcMinLΔ/+), and Villin-Cre;ApcMin/+;Lef1fl/fl (VApcMinL) mice (Fig. 7A).