The modest decrease in transcripts encoding several Bmps in the LApcL adenoma cells may also be associated with the ectopic crypt phenotype as previous studies have shown that Gremlin1 can decrease Bmp signaling and promote ectopic crypt formation and expansion of Lgr5− stem cells that function as cells of origin in Apc-mutant adenomas (32). The gene discussed is CLN5; the disease is adenoma.