Recent research has revealed that dithiazoleand dithiazine-based covalent inhibitors, in the order of sub-micromolarrange, can inactivate LAT1 and, in particular, two of them provokedcell death in high-LAT1-expressing cervical cancer cells (SiHa), thusshowing a cytotoxicity activity of these compounds.12 This suggested that the inhibition can be induced by theformation of the disulfide or trisulfide intermediate, as reportedin Scheme 1. This evidence concerns the gene SLC7A5 and cervical carcinoma.