Previously, Ccl2 has been reported to affect the activities of different kinds of neurons.[24] Blockage of Ccl2/CCR2 signaling attenuated neuropathic pain and depression.[24c] Here, when the primary cultured pyramidal neurons were treated with Ccl2, whole‐cell patch‐clamp recording displayed that Ccl2 administration efficiently repressed the frequencies and amplitudes of mEPSCs, and induced the frequencies and amplitudes of mIPSCs (Figure 5E,F). The gene discussed is CCR2; the disease is major depressive disorder.