In addition, the experimental results manifested that pcDNA-SSFA2 apparently reversed the depressive effect of sh-UBR1 on proliferation, migration, and invasion of A549 cells and the facilitation of apoptosis (Figure 5(c-g)), indicating that circ-UBR1 was involved in the progression of LC by modulating miR-545-5p/SSFA2 axis. This evidence concerns the gene UBR1 and laryngotracheoesophageal cleft.