AFC, AMH, and female age are important parameters to predict response to controlled ovarian stimulation (COS) and identify women who are unresponsive to treatment, at risk of canceling the cycle, and hyper-responsive women at higher risk of developing Ovarian Hyperstimulation Syndrome (OHSS) (Oliani et al., 2019). The gene discussed is AMH; the disease is ovarian hyperstimulation syndrome.