Based on the postfusion structure, the fully occupied Man5GlcNAc2 high-mannose glycan at the N1098 site in the postfusion S trimer of 16HBE (ACE2) cell origin virions may play a vital role in binding to DC- and L-SIGN receptors and facilitating DC- and L-SIGN-mediated infection. The gene discussed is ACE2; the disease is infection.