Our data cannot completely exclude the possibility of DC- and L-SIGN as a direct entry receptor for SARS-CoV-2 infection, since there may be virions in authentic infection which possess highly occupied high-mannose structures at N-glycan sites close to the RBD of prefusion trimer that are able to bind the receptors more tightly and trigger conformational changes in the S protein. This evidence concerns the gene PROS1 and infection.