In conclusion, these results demonstrate that hnRNPA2B1, which is the direct target gene of miR-188-5p, mediates the process of ER stress upregulating PKM2 expression and is related to some malignant clinicopathological behaviors of HCC, including poorer differentiation of HCC tissues, shorter overall survival, and sorafenib resistance. Here, HNRNPA2B1 is linked to hepatocellular carcinoma.