Recent studies and bioinformatics analysis have manifested that 47 miRNAs could regulate the energy metabolism reprogramming of tumor cells, 4 of them (miR33b-3p, miR-188-5p, miR22-5p, and miR301a-5p) expressed differentially in ER-stressed HCC cells.24, 25, 26 Furthermore, since PKM2 is upregulated in HCC, qRT-PCR (quantitative real-time-PCR) was used to verify the expression of nine downregulated miRNAs. The gene discussed is PKM; the disease is neoplasm.