In comparison with HCC samples with a low level of PKM2, we observed that GRP78 was highly expressed in HCC tissues with PKM2 high expression (12/34 versus 23/38, p = 0.0291), as well as ATF6 (13/34 versus 26/38, p = 0.0188), PERK (13/34 versus 22/38, p = 0.0117), and IRE1 (13/34 versus 27/38, p = 0.0019) (Figure 3C; Table S1). Here, HSPA5 is linked to hepatocellular carcinoma.