Interestingly, the same study revealed a signature of 5 cytokines (IL-1, IL-4, IL-7, IL-12 and IFN-α) that were elevated in untreated ECD patients with active disease compared to HC or individuals with other common inflammatory diseases such as rheumatoid arthritis, systemic sclerosis, or idiopathic inflammatory myopathies [33]. This evidence concerns the gene IL4 and rheumatoid arthritis.