CXCL10 and central nervous system cancer: Since high levels of CXCL10 were previously shown to activate the MAPK-ERK pathway in human glioma cells [26] and breast cancer cells [14, 27] we examined whether downregulation of this chemokine, following miR-15a-5p overexpression, affects the MAPK-ERK cascade in myeloid and lymphoid cells.