In respect to our finding of the relationship between presence of chlorine and decreased rate of tumor recurrence, it is possible that excess chlorine consequent to disturbances in the ionic channel function, specifically the chloride intracellular chanell 1 e 4 (CLIC1 CLIC4), lowers the cytoplasmic pH thereby inducing the tumor cell apoptosis. This evidence concerns the gene CLIC1 and neoplasm.