IFIH1 and infection: Among the common DEGs, some were first responders to the infection process, like the DDX58 and IFIH1 encoding the viral RNA sensors RIG-I and MDA5 respectively31, and their regulators, such as DHX58; others more downstream players of the response, such as OAS2 that is activated by detection of dsRNA to inhibit viral replication, IFIT2 that inhibits the expression of viral mRNAs, and BST2 that limits viral secretion.