In our meta-GWAS on rare variants in eczema, we uncover disease-associated exonic variants in the genes encoding dual specificity phosphatase 1 (DUSP1), neurogenic locus notch homolog protein 4 (NOTCH4), and solute carrier family 9 member A4 (SLC9A4). Here, NOTCH4 is linked to Eczematoid dermatitis.