A high level of TGF-β, as a consequence of chronic liver damage and the activation of fibroblast cells, is detected in HCC tissues and is correlated with poor prognosis of patients.10,12–14 Long non-coding RNAs (lncRNAs) are newly discovered non-protein-coding transcripts longer than 200 nucleotides. Here, TGFB1 is linked to hepatocellular carcinoma.