LncRNAs may interact with DNA, RNA or proteins to regulate various cell activities, like proliferation, apoptosis, and motility.15,16 Growing evidences indicate that dysfunction of lncRNAs plays vital roles in different physiological and pathological processes, including tumor development.17–19 To date, whether lncRNA regulates the TGF-β/SMAD signaling in HCC is still unknown. The gene discussed is TGFB1; the disease is neoplasm.