UBE2S and hepatocellular carcinoma: To further verify the correlation between UBE2S level and chemoresistance in HCC cells, we knocked down UBE2S in Huh7 and PLC/PRF/5 cells (Fig. 2F) and found that UBE2S knockdown suppressed the resistance of HCC cell to 5-FU and oxaliplatin (Fig. 2G–N).