In addition to a higher expression level of UBE2S in HCC than the corresponding normal tissues (Fig. 1C), we confirmed that the transcript level of UBE2S was obviously higher in HCC with aggressive phenotypes, including large tumor size (Fig. 1D), recurrence (Fig. 1E), and advanced TNM stage (Fig. 1F). The gene discussed is UBE2S; the disease is neoplasm.