UBE2S and hepatocellular carcinoma: Furthermore, it was showed that the binding of FOXM1 and RNA-polymerase II to the UBE2S promoter were inhibited in the ChIP assay when there was a low level of H3K4me3 in HCC cells (Fig. 4J), reflecting that the transcription activation of UBE2S by FOXM1 is dependent on H3K4me3 activation.