UBE2S and hepatocellular carcinoma: In addition, based on the RNA sequencing for FOXM1-knockdown HCC cells, we found that FOXM1 knockdown in HCC cells suppressed UBE2S mRNA level, FOXM1 pathway, AKT phosphorylation pathway, protein ubiquitination regulation as well as the drug response pathways (Fig. 3N–Q).