In addition, upregulation of p-AKT and enhancement of HCC cell chemoresistance upon FOXM1 overexpression were antagonized by UBE2S knockdown and AKT inhibitor, indicating that UBE2S is crucial for the PTEN-p-AKT signaling in the regulation of HCC chemoresistance. Here, UBE2S is linked to hepatocellular carcinoma.