Among a plethora of inflammatory cytokines involved in the inflammatory process, IL-6 and IL-8 have been considered to be two of the most important regulatory molecules in the inflammatory process and act as major mediators of the host response in pulpitis.38–40 They can be generally induced by many bacterial antigens, such as LPS, and are responsible for recruiting other inflammatory cells to the pulp chamber. This evidence concerns the gene IL6 and pulpitis.