In order to unravel pathway alterations in IO-MEPLs, we analyzed gene expression data from tumor samples of 8 previously genetically characterized human IO-MEPLs [9] along with a set of 16 intracranial embryonal tumors comprising ETMRs and MBs, including the molecular groups SHH-, WNT-, and Group 4-MB. The gene discussed is SHH; the disease is Mobius syndrome.