P53 is closely associated with multifaceted biological functions, including but not limited to DNA replication, modification and repair, cell cycle regulation, cell-fate determination, angiogenesis, anti-infection and immunity.5,6 P53 plays an important part in cell cycle by regulating cell cycle checkpoints of G1/S, S, and G2/M phases to bring a halt to cell cycle progression and DNA replication, while allowing DNA repair. Here, TP53 is linked to infection.