CD4 and neoplasm: Here, we detected in response to sensory neuron firing an increase in melanoma-infiltrating IL-17-producing CD4 + T cells (from 2.45 × 107 ± 6.05 × 106 to 30.78 × 107 ± 9.20 × 107 cells per mg of tumor) as well as in melanoma-infiltrating IL-17-producing CD8 + T cells (from 5.02 × 107 ± 0.90 × 107 to 20.08 × 107 ± 5.92 × 107 cells per mg of tumor) (Fig. 6A).