In tumor non-draining lymph nodes, we detected increases in IFN-γ-producing CD4 + T cells (from 5.73 × 106 ± 2.17 × 106 to 1.92 × 107 ± 4.23 × 106 cells per lymph node), in IFN-γ-producing CD8 + T cells (from 1.36 × 107 ± 5.57 × 106 to 4.77 × 107 ± 1.19 × 107 cells per lymph node), in IFN-γ-producing γδ T cells (from 2.27 × 106 ± 8.55 × 105 to 1.03 × 107 ± 3.22 × 106 cells per lymph node), and in IFN-γ-producing NK cells (from 1.80 × 105 ± 4.70 × 104 to 6.82 × 105 ± 1.53 × 105 cells per lymph node) (Fig. 7F). Here, CD8A is linked to neoplasm.