CD4 and neoplasm: We also observed, in the tumor-draining lymph nodes, increases in IFN-γ-producing CD4 + T cells (from 8.31 × 106 ± 2.65 × 106 to 1.94 × 107 ± 3.36 × 106 cells per lymph node), in IFN-γ-producing NK cells (from 4.72 × 104 ± 2.46 × 104 to 8.44 × 105 ± 2.22 × 105 cells per lymph node), in IL-17-producing CD8 + T cells (from 2.38 × 106 ± 4.27 × 105 to 1.28 × 107 ± 1.64 × 106 cells per lymph node), and in IL-17-producing NKT cells (from 2.35 × 106 ± 5.19 × 105 to 4.08 × 106 ± 5.00 × 105 cells per lymph node) after sensory neurons CNO-stimulation (Fig. 7E).