We found that the number of melanoma-infiltrating neutrophils and PMN-MDSCs was significantly decreased in the sensory neuron-overactivated mice (Nav1.8-Cre + /hM3Dq +) when compared to the controls (Nav1.8-Cre-/hM3Dq +) (from 12.02 × 107 ± 3.45 × 107 to 4.69 × 107 ± 7.10 × 106 PMN-MDSCs per mg of tumor; and from 10.45 × 107 ± 3.70 × 107 to 2.78 × 107 ± 5.65 × 106 neutrophils per mg of tumor) (Fig. 4A, B). This evidence concerns the gene SCN10A and melanoma.