CD4 and melanoma: We also observed after inhibition of sensory neurons firing a decrease in tumor-infiltrating CD4 + T cells (from 4.47 × 107 ± 1.15 × 107 to 1.73 × 107 ± 7.92 × 106 cells per mg of tumor) (Fig. 2E), in special, in IL-17-producing CD4 + T cells (from 1.63 × 107 ± 1.30 × 106 to 3.77 × 106 ± 3.27 × 106 cells per mg of tumor) (Fig. 2F), and a decrease in melanoma-infiltrating CD8 + T cells (from 3.27 × 106 ± 5.22 × 105 to 7.62 × 105 ± 6.78 × 105 cells per mg of tumor) (Fig. 2G).