NTRK1 and neoplasm: Moreover, as previously reported by Fukami et al. [24], TAE226 alone or in combination with SOR down-regulated the pTyr1135 form of the insulin growth factor 1 receptor β (pTyr1135IGF-1R), a well-known tyrosine kinase receptor crucial for tumour transformation and malignant cell survival (Fig. S3A and S3B).