While linkage studies traced susceptible variants in genes like CAPN10, TCF7L2, ENPP1, HNF4A, WFS1 and ACDC [1–4] most of which were not subsequently replicated [5], candidate gene studies simultaneously identified PPARG, KCNJ11, TCF7L2, IRS-1, IRS-2, PTPN1, LMNA and few other genes to be consistently associated with T2DM [6]. Here, IRS1 is linked to type 2 diabetes mellitus.