Overall, the results of the present study based on 92 SNPs suggest that the SNPs associated with T2DM mostly belong to the genes related to obesity and insulin signaling pathways and supplemented with the results of our earlier study of 15 SNPs from the 9 most important T2DM genes on the same cohort (Additional file 5: Table S5) provide by far the most comprehensive susceptibility profile for any major regional population/ethnic group hitherto studied in India with a possible exception to a very few [30] and the two recent GWAS each focused on a regional ethnic/linguistic group [17, 18]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.