IRS1 and type 2 diabetes mellitus: Although our earlier study was based on much larger cohort (758 cases and 621 controls as against the random subset of 500 cases and 500 controls for the present study of 92 SNPs), we reanalyzed the 15 SNP data in the reduced random subset and obtained qualitatively and quantitatively very similar results, in that seven of the 15 SNPs were found to be significant (P ≤ 0.05), risk conferring to T2DM and belong to TCF7L2, CDKAL1, IRS1 and CAPN10 genes.