IDH1 and neoplasm: We also analyzed the association of ME with any particular clinicopathologic factors, including age, gender, tumor grade, tumor size, PTBE size, tumor location, O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status, isocitrate dehydrogenase (IDH) mutation, and the co-deletion of chromosome arms 1p and 19q (1p/19q co-deletion), which would allow the CTV to be optimally adapted to individual situations.