SESN2 and cancer: Interestingly, multiple studies revealed higher expression levels of sestrin 2 in several cancers, including squamous cell carcinoma (SCC) and melanoma [38], metastatic melanoma tissues and cell lines [39], and endometrial cancer [40] compared with non-cancerous tissues or cell lines, and the increased expression of sestrin 2 was associated with poor prognosis [39, 40].