SESN2 and colorectal carcinoma: Wei et al. found that sestrin 2 overexpression inhibited proliferation and activated apoptosis in CRC cells (SW620 and LoVo lines) by activating AMPK and inhibiting the mTORC1 pathway, which downregulated proliferating cell nuclear antigen and survivin proteins and upregulated caspase proteins 3, 7, and 9 [56].