SESN2 and endometrial cancer: Knockdown of sestrin 2 with short hairpin RNA (shRNA) induced migration and promoted proliferation by increasing mRNA expression of the proliferation marker Ki-67 and decreasing mRNA expression of the cyclin-dependent kinase inhibitors 1A and 1B (cell cycle-associated genes) in HEC-1A and Ishikawa endometrial cancer cell lines, which are dependent on the mTORC1 pathway [40].