Interestingly, sestrin 2 also plays a significant role in growth inhibition of CRC, human head and neck cancer, medullary thyroid cancer, and breast cancer cells induced by the chemical drugs quercetin and 5-fluorouracil (5-FU), fisetin, 2-imino-6-methoxy-2H-chromene-3-carbothioamide (IMCA), and adiponectin, respectively. The gene discussed is ADIPOQ; the disease is breast cancer.