SESN2 and melanoma: Xia et al. found that CAP induced caspase 3/8-mediated apoptosis in A375 and A875 melanoma cell lines by increasing sestrin 2 expression, which activated p38 MAPK signaling and increased the expression of downstream Fas, Fas ligand, and iNOS; this process was reversed by using short interfering RNA targeting sestrin 2 [65].