Muscone, the main active ingredient in musk, promoted apoptosis of HepG2 hepatoma cells through the phosphorylated-protein kinase RNA-like endoplasmic reticulum kinase/activating transcription factor 4/DNA damage inducible transcript 3 mediated ER stress pathway and induced autophagy through the sestrin 2/AMPK/mTORC1 signaling pathway [49]. The gene discussed is SESN2; the disease is hepatocellular carcinoma.