Concerning the replication of phenotypes representative of ASD comorbidities, heterozygous mutant rodents of some exon-specific models (ex4-9|ANK [167], ex13-16|PDZ [140], ex13|PDZ [139, 176], ex11-21|SH3-PRO rat [135]) or mice with SHANK3 point mutations (ex21|PRO-R1117X [127], ex21|PRO-InsG3680 [127]), which are associated to human neuropsychiatric disorder, exhibited increased anxiety-levels compared to wildtype animals. Here, SHANK3 is linked to Anxiety.