Behavioral phenotypes, like increased repetitive routines, abnormal social behavior, elevated anxiety levels, impaired neuronal physiology, and altered PSD levels of HOMER, DLGAPs, NMDARs, AMPARs and other proteins, typify SHANK3-deficient murine animal models [78, 83, 90, 94, 118, 122, 124–128, 130, 132]. Here, SHANK3 is linked to Anxiety.