Elevated anxiety levels were also replicated in conditional KO-strategies, inducing SHANK3 deficiency in somatosensory neurons or cells derived from the caudal embryo (ex13-16|PDZ-AdvillinCre or -Cdx2Cre [140]), but also in GABAergic (ex14-16|PDZ-ViaatCre [131]) or DRD1-positive neurons (ex4-22|ALL-Drd1Cre [129]). The gene discussed is DRD1; the disease is Anxiety.