SHANK3 and schizophrenia: Abnormal social behavior was present in heterozygous mice from models targeting the ankyrin repeats (ex4-9|ANK [80, 122, 124]), the PDZ-domain (ex13-16|PDZ [140, 196], ex13|PDZ [139, 176]) or the prolin-rich region (ex21|PRO [154, 156, 177, 179, 197–199]), but also in heterozygous SHANK3-deficient rats (ex6|ANK [134, 180], ex11-21|SH3-PRO [135]) and models mimicking mutations associated to ASD or schizophrenia (ex8|ANK-Q321R [132], ex17|PRM-S685I [94], ex21|PRO-R1117X [127]).