Hypoactivity has been observed quite frequently and consistently in various models of SHANK3 deficiency including the deletion models ex4-22|ALL [128–130], ex11|SH3 [157], ex13-16|PDZ [83, 155, 159–163, 168, 182, 183, 188, 189], ex13|PDZ [139, 176], ex14-16|PDZ [131], and ex21|PRO [125, 178, 191], as well as in models mimicking point mutations associated to ASD or schizophrenia (ex21|PRO-InsG3728, -InsG3680, -R1117X [126, 127, 187]). Here, SHANK3 is linked to schizophrenia.