Abnormalities concerning tasks depending on sensorimotor function have been described in SHANK3-deficient rodents of the deletion models ex4-22|ALL [128, 130], ex4-9|ANK [78, 124, 155, 167], ex11|SH3 [123], and ex13-16|PDZ [83, 155, 159, 183], or mice harboring schizophrenia- and ASD-associated mutations (ex21|PRO-R1117X, -InsG3680 [127] or -InsG3728 [126, 187]). The gene discussed is SHANK3; the disease is schizophrenia.