Targeted SHANK3 deletion in somatosensory neurons or the caudal part of the embryo and neural tube (ex13-16|PDZ-AdvillinCre or -Cdx2Cre [140]) was sufficient to induce social deficits, avoidance behavior, anxiety, and sensory dysfunction in these mice, but did not result in stereotyped behavior or cognitive deficits. The gene discussed is SHANK3; the disease is Cognitive impairment.