Most interestingly, specific cKI-mediated restoration of SHANK3 levels in cells of the caudal embryo or somatosensory neurons (ex13-16|PDZ-Cdx2Cre, -AdvillinCre) was sufficient to normalize somatosensory deficits and abnormal tactile sensorimotor gating, as well as social interaction or recognition, avoidance behavior, and anxiety-like behaviors. Here, SHANK3 is linked to Anxiety.