Impaired motor learning was found in the deletion model targeting all isoforms of SHANK3 (ex4-22|ALL [130]), or in models mimicking mutations within exon 21 associated to neuropsychatric disorder (ex21|PRO-InsG3680, -R1117X, -InsG3728 [126, 127, 187]). This evidence concerns the gene SHANK3 and acute lymphoblastic leukemia.